Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Proteros Inks Deal to Provide Access to UC DCC's Screening Platform
In the deal with the University of Cincinnati, Drug Discovery Center, Proteros will provide biotechnology and drug firms access to UC DCC's ultra-high throughput and high-content screening platform along with a library of more than 340,000 drug-like compounds.
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