Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Thermo Fisher, Intrinsic Bioprobes Partner to Develop Mass Spec Assays
Thermo Fisher's sample handling and mass spectrometers will be integrated with IBI's proprietary immunoenrichment technology, and the two firms will develop assays and workflows for the detecting and quantifying low abundance proteins.
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