Regulation and Function of miR-218 in Gastric Cancer Metastasis
Tie, Pan et al., PLoS Genetics
Researchers describe a negative feedback system between Robo1, a Slit receptor, and miR-218, wherein “decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis.” The authors suggest that the restoration of miR-218 supresses Robo1 espression and inhibits tumor cell invasion.
Team Integrates Proteomics, MicroRNA Data to Find Osteoarthritis Gene Targets
Integrating microRNA and proteomic data with microRNA gene-target prediction algorithms, a research team created an “interactome” comprising 11 microRNAs and 58 proteins linked by 414 potential functional associations.
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