Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Team Integrates Proteomics, MicroRNA Data to Find Osteoarthritis Gene Targets
Integrating microRNA and proteomic data with microRNA gene-target prediction algorithms, a research team created an “interactome” comprising 11 microRNAs and 58 proteins linked by 414 potential functional associations.
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