Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Tale of Danaher: From Crippled Real Estate Investment Trust to Mass Spec Top Banana
Few in proteomics had probably ever heard of Danaher until two weeks ago. But the once-struggling real estate investment trust has been transformed by the Rales brothers into a successful global conglomerate, and by the end of the year is poised to become the top mass-spec firm in the world with the purchase of the ABI/MDS joint venture.
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