Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Q&A: FDA Researcher ID'ing Proteins as Biomarkers, Alternatives to Antibiotics for Food Animals
Jamie Boehmer and her staff are trying to find and identify biomarkers for inflammatory diseases in cows, as well as proteins that could serve as alternatives to antibiotics for use in food animals. The goal is to develop tools that will allow the FDA to regulate new drugs for diseases for which no treatments exist, or better treatments than currently exist.
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