Regulation and Function of miR-218 in Gastric Cancer Metastasis
Tie, Pan et al., PLoS Genetics
Researchers describe a negative feedback system between Robo1, a Slit receptor, and miR-218, wherein “decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis.” The authors suggest that the restoration of miR-218 supresses Robo1 espression and inhibits tumor cell invasion.
Proteros Fragments Inks First Deal to Uncover Protein Structure of Novel Protein Found by Axikin Pharma
The deal calls for Proteros to use its crystallography platform to decipher the X-ray structure of Axikin's protein, develop assays, identify active fragments, and develop the selected fragments into novel lead drug candidates.
New to GenomeWeb? Register quickly here.
