Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Proteomics Receives at Least $45M in FY 2009 NIH ARRA Grants; More to Follow in Coming Months
For fiscal year 2009, researchers in proteomics received at least 114 stimulus grants from the agency for projects ranging from new mass spec-based methods and technologies to biomarker discovery to instrument purchases.
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