Layer, Chiang, et al. Genome Biology
NGS-Based Peptide Display Platform Enables Proteome-Wide Screening for Autoantigens
The platform comprises synthetic oligonucleotides expressing roughly 413,000 36-residue peptides covering all open reading frames in the human genome. They are engineered for phage display and can be quantified via phage immunoprecipitation followed by next-generation sequencing.
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