NCI-Led Study Demonstrates Reproducibility of SID-MRM-MS for Protein Biomarker Verification

July 09, 2009

Individual labs have shown that multiple reaction monitoring coupled with isotope dilution mass spectrometry, or SID-MRM-MS, can be used to quantify candidate protein biomarkers in plasma, but until now no one had proven the interlaboratory reproducibility of the method or the transferability of the assays across different labs.

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Young Investigator Profile

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Assistant Professor
Columbia University

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The Basu research group is looking at how activation induced cytidine deaminase (AID) predominately targets V genes and switch sequences, the mechanisms by which physiological targets of AID are repaired in a mutagenic fashion in B cells, how AID is prevented from acting as a pleiotropic cellular mutagen, and the physiological role of AID in non-B cells.
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February 07, 2012

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Amazon Cuts Cloud Storage Prices

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Double Down

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Papers of Note

Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
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Genomic Epidemiology of the 2011 Escherichia coli O104:H4 Outbreaks
Grad, Lipsitch et al., PNAS
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Members of the International Stroke Genetics Consortium and the Wellcome Trust Case Control Consortium 2 did a GWAS involving thousands of individuals of European descent with or without a history of stroke and found a new genetic variant that contributes to a form of stroke called large vessel ischemic stroke. The variant was found in in the histone deacetylase 9 coding gene HDAC9 on chromosome 7.
Business
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Funding
Canada launched a new program that will pump C$67.5 million (US$67.3 million) into projects that will use genomics-based research to advance personalized healthcare. The 2012 Large-Scale Applied Research Project Competition in Genomics and Personalized Health is funded with C$40 million from Genome Canada, C$22.5 million from the Canadian Institute of Health Research, and C$5 million from the Cancer Stem Cell Consortium.
Genome Technology Magazine
The National Center for Biotechnology Information's Teresa Przytycka and her team have developed a pathway-centric computational approach, which is based on eQTL analysis, graph theoretical techniques, and combinatorial algorithms, to identify causative genes for complex diseases. In a paper, her team applied the approach to glioblastoma multiforme, and they identified not only putative causal genes, but also potential nodes and pathways linking those genes.

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NCI-Led Study Demonstrates Reproducibility of SID-MRM-MS for Protein Biomarker Verification

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