Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Horse Racing Enters Proteomics Age: UK Firm Developing Technology to Detect Steroid Use in Ponies
As performance-enhancing drugs have evolved from small molecules to substances that traditional test methods cannot detect, Quotient Bioresearch is developing a biomarker-based approach to test not for specific molecules in a horse's system but for biological changes that could be indications of doping.
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