Family-Based Whole-Genome Sequencing Reveals Candidates for Mendelian Disease
Roach, Glusman et al., Science
Researchers at the Institute for Systems Biology and Complete Genomics have identified candidate disease-causing genes for Miller syndrome and ciliary dyskinesia, both Mendelian disorders. They sequenced the genomes of a family of four, allowing them to determine recombination sites with precision (at 99.999 percent accuracy) and identify rare single-nucleotide polymorphisms. "Our results demonstrate the unique value of complete genome sequencing in families," the authors write.
FTC Asks MDS, Danaher for More Info; Anticipated Closing of Deals Pushed Back to Q1 2010
The request is the FTC's second request for information and relates to a global market segment that the two companies anticipate will generate less than $50 million in revenues annually for all sellers combined, MDS said in a statement.
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