Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Better than Gold? GWC Receives $100K ARRA Grant to Develop New Substrate for Protein Arrays
The "carbon-on-metal" technology would address limitations to gold as a material for protein array development, making such arrays less susceptible to non-specific binding, less prone to denaturing proteins, and more reusable.
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