Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Awaiting FDA OK for OVA1 Test, Vermillion Hires Bank to Explore ‘Alternatives’ for Dx
The bank, ThinkPanmure, will help Vermillion identify and evaluate “strategic alternatives intended to enhance the potential” of the test, called OVA1, as well as for its diagnostic for peripheral arterial disease, VASCLIR. Vermillion did not define the alternatives.
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