Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Admitting Its Limitations, Bio-Rad Contends SELDI Still Valuable for Biomarker Discovery
Acknowledging that researchers need to pay attentiohttp://www.genomeweb.com/Admin/cgi-bin/udt/im.list.pages?client_id=proteomonitor&issue_id=3507&story_id=0 Issue Management > Edit Storyn to study design and workflow, Bio-Rad is issuing recommendations and guidelines for the short term and identifying further applications and improving the SELDI technology in the longer term.
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