Researchers in Spain report in Modern Pathology on their study of 47 patients with age-related EBV-positive diffuse large B-cell lymphoma. They found that "EBV-positive diffuse large B-cell lymphoma of the elderly is an aggressive, clonal B-cell neoplasm with prominent nuclear factor-kB pathway activation in the neoplastic cells," and add that "these tumors behave aggressively and have poor [overall survival and [progression-free survival] with conventional treatments." The researchers thus recommend that alternate therapies should be tested to treat patients with age-related EBV-positive diffuse large B-cell lymphoma.
Also in Modern Pathology, Mayo Clinic researchers discuss the range of mucosal CD30-positive T-cell lymphoproliferation disorders. Drawing on data from 15 patients with the disorders who visited their clinic, the researchers say that "mucosal CD30-positive T-cell lymphoproliferations share features with cutaneous CD30-positive T-cell lymphoproliferative disorders, and require clinical staging for stratification into primary and secondary types" and that "primary cases have clinicopathologic features closer to primary cutaneous disease than to systemic anaplastic large cell lymphoma, including indolent clinical behavior." The researchers add that better understanding of the disorders will prevent misdiagnosis and overtreatment.