In an Experimental and Molecular Pathology paper published online in advance this week, scientists in Italy report on their qRT-PCR-based investigation of 5-HTT expression in 10 cases of sudden infant death syndrome, or SIDS. While the team found 5-HTT expression levels comparable to those seen in the control case for nine of the SIDS cases, in one experimental case it found "a remarkable reduction in the expression of the gene," the authors write. "It is presumable that, despite the presence of the same S/S genotype, the different genetic background could influence the transcript stability and that the polymorphic variant of the 5-HTT gene could respond differently to the external environmental stimuli."
Elsewhere in the journal, Third Affiliated Hospital of Harbin Medical University's Ge Yu and Jing Wang discuss the significance of HABP1/P32/gC1qR expression and the effects of such in 131patients with stage III-IV ovarian serous carcinoma. Yu and Wang found that overexpression of HABP1 is related to a decrease in overall survival and progression-free survival, and further, that such " may be utilized as a prognostic marker for stage III/IV patients," they write in Experimental and Molecular Pathology.