Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Q&A: UNCs Webster-Cyriaque Discusses qPCR Assay for Common HPV Types in Genital, Oral Tissue
The assay may provide insight into the relationships between various HPV types and their associated diseases — not just cervical cancer, but also potentially head and neck cancers and HPV-associated warts.
New to GenomeWeb? Register quickly here.