Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Transgenomic Sales Slip 6 Percent; Firm Sees Strong Finish for Year
November 06, 2009
The firm trimmed its losses and selling costs, and it expects to launch a K-Ras test shortly.
Full-text access for registered users only.
Existing users login here.
New to GenomeWeb? Register quickly here for free access.
New to GenomeWeb? Register quickly here for free access.
Related Stories
- Transgenomic, MD Anderson to Evaluate Ice Cold-PCR for CTC Mutation Detection
March 22, 2012 / PCR Insider - Transgenomic Strikes Pair of Distribution Deals for Mutation Detection, CTC Analysis
November 10, 2011 / PCR Insider - Dana-Farber Team Developing High-Throughput Cold-PCR for NGS-Based Mutation Analysis
September 29, 2011 / PCR Insider - Transgenomic Expands License from Dana Farber to Include Ice COLD-PCR
March 14, 2011 / GenomeWeb Daily News - Transgenomic Eyes COLD-PCR as Key Revenue Driver via Pharma Pacts, Dx Sales and Services
February 25, 2010 / PCR Insider