Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Qiagen Bets SABiosciences' Pathway-Focused PCR Panels Will Help Develop Companion Dxs
Qiagen’s goal is to enable its customers to take an assay in a very early stage of discovery and validation and, “without transitioning platforms — to seamlessly move that into a companion diagnostic candidate if they so wish."
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