Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
NIAID Awards Akonni $3.2M to Combine PCR, Microarray Tech for Low-Cost, Rapid Flu Detection
While the system will provide a level of multiplexing that is "more than conventional PCR, but not as high as microarrays in general," the expected cost "is on par with, and in some respects lower than, what hospitals and clinics are paying for real-time PCR."
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