Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Fluidigm Licenses Megapixel Digital PCR Method from University of British Columbia
July 14, 2011
The technology could improve the utility of digital PCR in diagnostic applications, and help drive the technique's adoption as a low-cost alternative to quantitative real-time PCR for applications such as copy number variation, rare allele detection, and single-cell gene expression analysis.
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