Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Akonni Wins $435K SBIR Grant to Develop POC Tuberculosis Dx on PCR Array Technology
In addition, Akonni is developing tests based on the biochip technology for a number of other infectious agents, and is designing and testing an integrated instrument platform to perform the tests, with the ultimate goal of seeking US regulatory clearance.
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