Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Ontario Institute for Cancer Research Plans Hires, Increased Commercial Activities
The institute intends to add more than 40 people at its hub in Toronto and step up its Intellectual Property Development and Commercialization program, which awards pre-commercial "valley of death" funding toward commercializing intellectual property based at least partially on research carried out in Ontario.
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