Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
FDA, NIH Team IDs Murine Leukemia Virus Genes in Blood of Chronic Fatigue Syndrome Patients
September 02, 2010
The findings support a prior study that identified a similar virus in many CFS sufferers. However, it also conflicts with the results of several other studies that failed to detect gene sequences from either virus in CFS patients, raising questions about the PCR methods employed.
Full-text access for premium subscribers only.
Existing premium subscribers login here.
New to GenomeWeb? Register quickly here.
New to GenomeWeb? Register quickly here.
Related Stories
- CDC Team Finds Widespread Murine Virus, Mouse DNA Contamination in Commercial PCR Reagents
January 5, 2012 / PCR Insider - FDA Approves Roche's Companion Dx and Drug for Melanoma
August 17, 2011 / GenomeWeb Daily News - NIH Funds MBio $5.2M to Develop Influenza Test
July 20, 2011 / GenomeWeb Daily News - PCR Testing Casts Doubt on XMRV Link to Chronic Fatigue Syndrome; Reveals Reagent Contamination
June 9, 2011 / PCR Insider - Idaho Tech Gets FDA OK for Respiratory Dx; Expects Approval for Improved Panel Soon
April 28, 2011 / PCR Insider