A postdoctoral position in computational biology/systems medicine is available at the Saez-Rodriguez group (www.ebi.ac.uk/saezrodriguez) at the European Bioinformatics Institute (EMBL-EBI) located on the Wellcome Trust Genome Campus near Cambridge in the UK.
The Postdoctoral Fellow will be working on a project funded by the Centre for Therapeutic Target Validation (CTTV), a collaboration between EMBL-EBI, the Wellcome Trust Sanger Institute (WTSI) and GlaxoSmithKline (http://www.targetvalidation.org/). This is a public-private initiative to generate evidence on the validity of therapeutic targets, and is committed to sharing its data openly with the scientific community.
The Fellow will apply existing methods and develop novel ones to derive signatures of signalling pathway activity via various strategies that use gene expression as readouts of signalling deregulation. Deregulation of signal transduction underpins many diseases including cancer and autoimmune diseases. A popular rationale to target discovery is to identify these pathways and develop therapeutic agents that revert their deregulation. Thus, this analysis will provide novel targets for drug discovery that will be validated experimentally.
EMBL-EBI is part of the European Molecular Biology Laboratory (EMBL) and is located on the Wellcome Trust Genome Campus near Cambridge in the UK. We are a world-leading bioinformatics centre providing biological data to the scientific community with expertise in data storage, analysis and representation. We provide a dynamic, international working environment and has close ties with both the University of Cambridge and the Wellcome Trust Sanger Institute. EMBL-EBI staff enjoy many benefits including excellent sports facilities, a free shuttle bus to Cambridge and other nearby centres, an active sports and social club and an attractive working environment set in 55 acres of parkland.