Sr. Scientist/Group Leader - Protein Engineering

Avitide, Inc.
Job Location: 
Lebanon, NH
Job Description: 

Avitide is a biotechnology company which provides a technology platform that discovers and develops high-performance custom affinity purification solutions for the biopharmaceutical industry. Avitide is building a motivated and highly integrated, interdisciplinary team to pursue the rapid development of custom affinity purification resins for our biopharmaceutical clients. These products will enable and accelerate the delivery of new medicines to patients.

Avitide's founding team brings substantial expertise and a track record of success in commercializing innovation in discovery platforms and bioprocess technologies. Avitide is financed by top-tier venture capital firms such as SV Life Sciences, Polaris Venture Partners, OrbiMed Advisors, and Borealis Ventures.

Avitide is located in New Hampshire’s beautiful Upper Connecticut River Valley, and is minutes from Dartmouth College, the Geisel School of Medicine, the Thayer School of Engineering, the Tuck School of Business, and Dartmouth-Hitchcock Medical Center. The area is renowned for its premier skiing, hiking, canoeing, and kayaking. Avitide offers individually tailored compensation packages comprised of competitive salary, bonus, benefits, and equity components.

About This Position

A successful candidate will join Avitide’s Affinity Ligand Discovery team to develop innovative purification solutions to accelerate our partner’s clinical biopharmaceutical pipeline. Critical responsibilities include the design, development and execution of discovery methods and engineering novel ligands for biopharmaceutical purification. The candidate will provide foundational expertise in genetic library construction, display and selection methodologies, and technical leadership to peptide and protein engineering initiatives within Avitide’s platform affinity purification technology workflows. Avitide seeks candidates who are highly self-motivated and can work in a collaborative fashion with other interdisciplinary team members in a fast-paced and exciting work environment.

Qualifications and Experience:

Extensive experience with phage, yeast, ribosomal, or other display technology for protein engineering and/or peptide/protein discovery applications
Strong experience in the design, development, and construction of genetic libraries to improve binding affinity, selectivity, or physical characteristics of binding molecules
Degree (BS/MS/PhD) in biological sciences, biochemistry, or engineering
BS 10+ years/MS 7+ years/PhD 4+ years of industrial experience in a protein engineering or antibody/binding-scaffold discovery research laboratory setting
Demonstrated history of strong hands-on ability, problem solving, and independent experimental design and execution

Duties and Responsibilities:

Develop and optimize peptide/protein libraries and methods for the discovery of biopharmaceutical purification ligands.
Develop and engineer novel binding molecules for purposes of biopharmaceutical affinity purification
Design, develop, and execute analytical assays to assess discovery methodologies and ligand function
Work closely with the Ligand Discovery and High-throughput Production teams to rapidly identify affinity purification leads

Desirable Skills:

Depth of experience in molecular biology and protein engineering methodologies
Strong structure-activity knowledge as it pertains to peptide or protein binding molecules
NGS and bioinformatic analysis experience highly desirable
Experience in managing multiple parallel discovery projects

Avitide Cultural Qualities

Demonstrate creativity and innovation
Actively contribute to our collaborative team culture
Ability to work autonomously and effectively under broad directives
Agile and quick to adapt
Excellent and timely communication skills