Senior Genomics Laboratory Research & Development Associate

Organization: 
Genomics Laboratory - 120
Job Location: 
Redwood City, California, United States, 94063
Job Description: 

The Sr. Laboratory Associate will participate in integrated teams focusing on specific research, development and clinical study programs. Programs will consist of designing and validating gene expression and other genomics assays for candidate biomarker panels and testing them in exploratory clinical feasibility studies using quantitative real-time-PCR or NGS platforms; defining and optimizing new laboratory methods as needed to address technical challenges that emerge during the course of research and development programs; and meeting ‘next generation’ demands in laboratory process scale and refinement by evolving new versions of existing laboratory processes and methods. The Sr. Laboratory Associate will take responsibility for executing assigned components of specific phases of a Research and Development program. The Sr. Laboratory Associate may be a technical lead of studies in the laboratory.

Requirements: 
  • The Sr. Laboratory Associate will have responsibility for conducting assigned laboratory components of each phase of a Research and Development program. Tasks may include working with cross-functional teams to design and optimize laboratory processes, analyzing study samples with defined laboratory processes, troubleshooting laboratory process related issues during the conduct of studies, writing laboratory protocols or reports, and reviewing study synopsis or reports.
  • The Sr. Laboratory Associate may supervise the work of laboratory associates and assistants responsible for assembling and verifying study reagents and materials and for conducting the laboratory processes as described in the laboratory protocols.
  • The Sr. Laboratory Associate will be responsible for maintaining equipment and instruments in good operational condition, recognize any malfunctions and troubleshoot as needed.
  • Other responsibilities as assigned

REQUIRED

  • BS or MS and a minimum of 5 years of relevant laboratory experience, preferably in a diagnostic or research environment
  • Demonstrated capability to work effectively in cross-functional teams
  • A track record of successfully completing complex assignments and meeting goals within aggressive timelines
  • Experience with standard molecular biology techniques, especially in the areas of nucleic acid extraction from various biological specimens including formalin-fixed paraffin-embedded tissue and fluorescent quantitative RT-PCR
  • Experience with library preparation for massively parallel sequencing and sequencing platforms (MiSeq, HiSeq, PGM and Proton)
  • Knowledge and hands-on experience with various liquid handling robotics platforms as well as adapting and validating assays for robotics
  • Knowledge of essential laboratory methods such as qPCR, bioanalyzer, DNA/RNA quantitation, PCR, next generation sequencing
  • Experience conducting laboratory processes, including assays, data acquisition, and data quality control
  • Demonstrated capability planning laboratory schedules to support development and clinical studies, including work schedules and equipment usage
  • Experience monitoring quality of data and troubleshooting technical problems during studies
  • Demonstrated capability in evaluation and development of methods and procedures, writing laboratory protocols, SOPs and participating in data analysis
  • Strong written and oral communication skills with ability to maintain open communication with internal employees, managers and external partners as needed
  • Excellent organizational and planning skills
  • Practical knowledge of LIMS/database query tools and electronic laboratory notebook
  • Proficiency in using basic word processing and spreadsheet applications
  • Able to integrate and apply feedback in a professional manner
  • Able to prioritize and drive to results with a high emphasis on quality

DESIRED

  • Experience working in a controlled, high-throughput and fast paced environment
  • Experience with automated robotic systems
  • Experience with GLP and/or GMP

TRAVEL, PHYSICAL DEMANDS AND WORK ENVIRONMENT:

Select or Delete Below as Appropriate:

  • No travel Requirements
  • Standing or sitting for long periods of time may be necessary
  • May be exposed to hazardous materials, tissue specimens and instruments with moving parts, lasers, heating and freezing elements, and high speed centrifugation
  • Repetitive manual pipetting may be necessary

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Contact Information: 

Human Resource
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