Layer, Chiang, et al. Genome Biology
We are looking for a highly qualified and motivated scientist with in depth experience in next-generation sequencing, technology development, and related bioinformatics analysis.
Responsibilities will include:
Lead a group of scientific associates to design and conduct experiments, to interpret and challenge experimental results and manage the day-to-day tasks of the genomics laboratory
Test and apply new scientific methodologies and techniques to identify and develop innovative solutions to answer experimental / scientific questions
Interact with diverse project teams and provide expertise in genomic technologies and experimental design
Lead development and production efforts for targeted sequencing and other biomarker assays
Conduct library prep, QC, and sequencing work for Illumina instruments
Work closely with bioinformatics colleagues to analyze data and assess data quality
Contribute to the design and implementation of internal data analysis pipelines and LIMS systems
Investigate and evaluate new technologies and make recommendations for implementation
Develop protocols for new technologies and oversee pilot studies
Assist software engineers with the design of informatics around new technologies
Write internal reports and contribute to external publications
Conduct and supervise lab to ensure compliance with Novartis HSE guidelines and policies
To qualify, candidates must have:
BS/MS in a relevant discipline with at least 5 years of relevant work experience
Hands-on experience with the operation of NGS and associated instrumentation. The ideal candidate will be experienced in various types of NGS data (Exome, RNA-Seq, etc.)
Experience with complementary technologies (e.g. multiplex PCR, qPCR, digital PCR, Nanostring, Raindance, etc)
Familiarity with liquid handling automation, especially with how automation may be used in NGS workflows
Familiarity with lab operations in a quality regulated environment (CLIA, GCLP, GLP, etc) is preferred
Candidates are required to have good organizational and interpersonal skills. Critical thinking skills and the ability to work both independently and collaboratively in a team environment are essential.
To learn more and apply, please visit:
About Our Organization:
About Novartis Institute for Biomedical Research:
The Novartis Institutes for BioMedical Research is the global pharmaceutical research organization for Novartis. The NIBR research network is comprised of more than 6,000 scientists, physicians, and business professionals working together across 10 locations around the world to discover innovative medicines that treat diseases with high unmet medical need. Novartis employs more than 2,000 associates in Cambridge, making it the city’s largest private employer and ideally situated in one of the leading life science communities in the world.
NIBR conducts research globally with sites in Emeryville, California; Cambridge, MA; East Hanover, NJ; Basel, Switzerland; Horsham, UK; and Shanghai, China.
About the Next Generation Sequencing Group
The ability to sequence each patient’s genome in great detail, quickly and inexpensively, is changing the practice of medicine. At NIBR, we are dedicated to the development of therapies that improve clinical outcomes for patients. Next generation sequencing and other cutting-edge molecular characterization technologies will be important tools for discovering breakthrough therapeutics, and for delivering the right medicines to the right patients.
The NGDx team leverages cutting-edge technologies such as next generation sequencing for characterizing human tissues, by individual lesions and by pathway signatures relevant to therapeutic response. The goal is to develop a robust and comprehensive molecular profile for each patient. To this end, the group will begin by developing capabilities to characterize therapeutically relevant genetic lesions and pathway signatures in human cancer.