Director, Gene Targeting and Transgenic Mouse Core Cold Spring Harbor Laboratory

Cold Spring Harbor Laboratory
Job Location: 
Cold Spring Harbor, New York
Based on level of experience

Comprehensive benefits package

Job Description: 

Director, Gene Targeting and Transgenic Mouse Core Cold Spring Harbor Laboratory

Cold Spring Harbor Laboratory has an opening for a Ph.D. level scientist to oversee the Gene Targeting Shared Resource. This Shared Resource provides expertise in the construction and management of genetically modified mouse strains. Services provided include gene targeting in mouse embryonic stem (ES) cells, generation of ES cell-derived chimeras via blastocyst injection, production of ES cell-derived mice by tetraploid blastocyst injection, the generation of transgenic mice by pronuclear injection of plasmid/BAC constructs, karyotyping, and cryopreservation. This Shared Resource has been used to generate a variety of genetically defined mouse models of human diseases, primarily cancer and neurological disorders. These models are being used to understand the onset and progression of the diseases, to predict response to drug treatment, and to test novel drugs and treatment strategies. Many of these models take advantage of shRNA technologies for control of target gene expression.

The Gene Targeting Shared Resource Director will manage the day-to-day operations of the Gene Targeting Shared Resource as well as participate in experimental design and technical procedures. The director will also be responsible for developing new techniques and protocols to introduce into the Shared Resource, including the establishment and maintenance of quality control criteria for all services.


A Ph.D. in experimental embryology, animal science, reproductive biology, or a related field with at least two years post-doctoral experience is preferred. Applicants must have a proven track record with all aspects of genetic manipulation of the mouse germline, both via pronuclear injection and modification of ES. Experience with iPS cells and CRISPR/Cas technology is a plus. Excellent supervisory and management skills and good communication and writing skills are required.

Contact Information: 

Interested candidates must apply for this position via the CSHL website at:

Position Number 00898-R

Candidates may also send a cover letter, CV, description of prior experience, and the names of three references to Include Transgenics 2014 in the subject line.

About Our Organization: 

Cold Spring Harbor Laboratory is a world-renowned research and educational institution with programs in cancer, neuroscience, plant biology, genomics, and quantitative biology. The Laboratory is recognized internationally for its excellence in research and educational activities.

For more information about CSHL,please visit us at:

CSHL is an Equal Opportunity Employer.