Post-Doctoral Research Fellow - DNA Repair and Mutation Research

Organization: 
Fred Hutchinson Cancer Research Center & Seattle Cancer Care Alliance
Job Location: 
Seattle, WA
Job Description: 

Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone marrow transplantation, the Center's four scientific divisions collaborate to form a unique environment for conducting basic and applied science.

The Hutchinson Center, in collaboration with its clinical and research partners, the University of Washington and Children's Hospital and Regional Medical Center, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Join us and make a difference.

The Bielas lab (http://labs.fhcrc.org/bielas/), in the Translation Research Program at the Fred Hutchinson Cancer Research Center, studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the pathogenesis of cancer and age-related disease. Recent findings in the lab, attained with the use of exceptionally sensitive assays for quantifying both nuclear and mitochondrial mutations, have guided our principal research interest toward the application of DNA mutations as novel molecular disease markers for diagnostics.

We are currently investigating the relationships among metabolism, mtDNA mutagenesis, and apoptosis, as well as the prevalence of cancer-associated mitochondrial and nuclear mutations disseminated in bodily fluids as a marker for early detection, minimal residual disease, and recurrence. We have also initiated studies to explore the utility of genome mutational load as an additional, more quantitative index of tumor therapeutic response, clinical stage, and progression.

PhD in a relevant biological field, with a strong background in molecular and cellular biology including: cloning, transfection/infection of cells, PCR, and Southern/Northern/Western blotting. Experience in tissue culture, QPCR, mutational assays, FACs, and especially programming (i.e. a Computational Biologist) is highly desirable.

Candidates should be able to demonstrate a track record of independent productive research, show willingness to help guide junior lab members, have strong organizational, written, and verbal skills, and possess the ability to work both independently and as part of a laboratory team.

Please include a CV, cover letter, and list of three references in your application.

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