Computational biologist - RNA-seq

Seven Bridges Genomics
Job Location: 
Cambridge, MA
Job Description: 

You know genomics and you like to share your knowledge. You have broad competence in the field and expert knowledge of some part of it.

You know how to tell good information from bad, how to draw interesting and intellectually responsible results from good information; and how to communicate those results in an accurate and engaging way.

You are ready to refine your knowledge and to keep learning about a quickly changing field.

You understand significance testing in differential expression. You can explain the differences between Cuffdiff and DESeq, both in intuitive terms and more technically. You understand normalization and the issues it raises.
You know enough about the upstream RNA-Seq protocols to be able to interpret their results appropriately. You also know the basic biology of RNA: gene structure, tRNA, homopolymers and poly(A) tails, promoter sites, repressors, cryptic unstable transcripts, isoforms, and so on.
You have worked with large RNA-Seq data sets. You know annotation databases and the related ecosystem of standards and tools. You’re familiar with RefSeq and GENCODE. You are familiar with tools like TopHat, Bowtie, STAR, and BLAT, and you’ve thought carefully about how RNA data presents specific challenges for alignment algorithms.

It would be nice if you also have experience with single-cell transcriptomes and strand-specific data.

You will work with our industry-leading team and data to plan, write, and publish articles and results. You will find the best venues and methods to explain your results to the community. You have academic publications, a good blog, or other experience writing about science.

  • An advanced degree in biology, bioinformatics, or a related discipline.
  • The proven ability to write about science in a rigorous, academic manner.
  • The proven ability to communicate science to non-expert audiences.
  • We are also looking for a strong cultural fit, as we value our team more than anything else and we like to learn from each other and share the knowledge. In return, we offer a relaxed and open work environment, great work conditions, and first-hand involvement in one of the most exciting fields of science that is laying down the foundations of modern personalized medicine.

    Contact Information: 

    please contact for all inquiries and resume submissions with cover letter.

    About Our Organization: 

    Seven Bridges Genomics ( is building the most advanced cloud computing platform for genomics data analysis on the market. Voted “Best of Bio IT World 2013”, we enable researchers to analyze genomic data faster and more efficiently than ever possible, so that they can focus on advancing the fields of genomics and personalized medicine.