Post-Doctoral Research Fellow, Tumor Microenvironment

Organization: 
Fred Hutchinson Cancer Research Center & Seattle Cancer Care Alliance
Job Location: 
Seattle,WA
Job Description: 

Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, the Center's five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Hutchinson Center, in collaboration with its clinical and research partners, the University of Washington and Seattle Children's, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Join us and make a difference!

A laboratory in Fred Hutchinson Cancer Research Center's Translational Research Program within the Division of Public Health Sciences, is looking for a highly motivated Postdoctoral Research Fellow. The candidate would join the Laboratory for the Study of Metastatic Microenvironments, directed by Dr. Cyrus Ghajar, which focuses on understanding the biology underlying disseminated tumor cell (DTC) dormancy (see Ghajar et al., Nature Cell Biology 2013) and formulating therapeutic means to eradicate dormant DTCs.

The candidate will conduct research aimed at uncovering the molecular mechanisms underlying DTC dormancy in the brain, and test therapeutic regimens aimed specifically at eliminating these tumor cell populations. The candidate will utilize an array of innovative and sophisticated techniques to conduct this work, including three-dimensional cell culture models, murine and Danio rerio models and intravital imaging approaches. The ideal candidate would be interested applying these techniques to better understand tumor-microenvironment interactions in the context of metastatic sites.

A Ph.D. in the field of bioengineering, molecular/cell biology, biochemistry, or biophysics and a demonstrated track record of productive doctoral research are required. A strong publication record and eligibility and desire to apply for future fellowships are also required. The candidate must also be experienced in essential techniques in molecular and cellular biology including cloning, transfection/infection of cells, PCR, Western blotting, tissue culture (2D and 3D approaches), immunohistochemistry and immunofluorescence, and imaging.

A candidate with experience in live cell imaging, developing quantitative image analysis approaches, and experience working in murine or Danio rerio tumor or metastasis models is strongly desired.

The successful candidate must have excellent communication and organizational skills, the ability to develop creative approaches to experimental design and be able to function independently and work collaboratively.

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