Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases.
Recognized internationally for its pioneering work in bone-marrow transplantation, the Center's five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Hutchinson Center, in collaboration with its clinical and research partners, the University of Washington and Seattle Children's, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Join us and make a difference!
We are seeking a highly motivated PhD level scientist to lead a multidisciplinary project in cancer drug target discovery and development based in the laboratories of Drs. Christopher Kemp and Carla Grandori.
The Kemp/Grandori laboratories are one of eleven centers in the country to join the NCI funded Cancer Target Discovery and Development (CTD2) Network, which aims to bridge the gap between the comprehensive molecular characterizations of human cancers and the ability to apply the information to improve patient outcomes.
Specifically, the CTD2 Network aims to identify novel therapeutic targets from The Cancer Genome Atlas (TCGA), Cancer Genomic Characterization Initiative (CGCI) and other data sets. The CTD2 centers have established a highly collaborative network to achieve these goals and more information can be found at http://ocg.cancer.gov/programs/ctd2/centers.
This Research Associate position will oversee all aspects of a project that will apply state of the art functional genetics and high throughput screening approaches to identify genes required for cancer cell survival and, through bioinformatic and functional assays, to validate these as viable drug targets.
This will involve generating and characterizing primary cell cultures, performing high throughput screening, and prioritizing targets with bioinformatics. He/she will also generate in vitro and in vivo target validation using mouse models.
The ideal applicant will have broad experience in cancer and molecular biology, bioinformatics, primary cell culture, and -omics approaches to cancer medicine. Experience with biochemistry, molecular pharmacology, animal models and/or clinical oncology would be a plus.
This is an outstanding opportunity to perform groundbreaking cancer research with direct clinical applications. An example of this approach can be found in Toyoshima et al. "Functional genomics identifies therapeutic targets for MYC-driven cancer" Proc Natl Acad Sci USA, 2012 (PMID 22623531).
A Ph.D. in the field of molecular biology, biochemistry, genetics or related discipline and a demonstrated track record of successful research and publication are required. The successful candidate must have excellent communication and organizational skills, the ability to implement creative experimental approaches and the ability to function independently and work collaboratively.
Salary is based on the NIH scale and the funding for this position is for three to four years, depending on productivity. Please note that at least two letters of recommendation will be requested as part of the screening process. Please include a cover letter detailing your interest and suitability for this position with your application.
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