Sr. Scientist - Myers Lab

HudsonAlpha Institute for Biotechnology
Job Location: 
Huntsville, AL

HudsonAlpha offers a competitve benefits package

Job Description: 

Richard M. Myers's laboratory develops and applies high throughput DNA sequencing analysis technologies to study the genetics and genomics of human biology and disease. Projects include genomic and genetic analysis of cancer, neurological diseases, childhood inherited disorders, differential drug response and basic biological studies, including participating inthe ENCODE Project.

Dr. Myers is President and Director of HudsonAlpha Institute. Prior to joining the Institute, Dr. Myers was Chair of the Department of Genetics and Director of the Stanford Human Genome Center at the Stanford University School of Medicine. His experience leading large laboratories, together with his expertise in genomics and genetics, provides an opportunity for high-caliber research and professional development.

We are seeking a talented individual for a Senior Scientist position in the Myers laboratory to help lead our efforts in the NIH-funded ENCODE Project, in which we have been contributors since the project began 12 years ago. This exciting project is using a wide range of genome-wide, mostly next-generation DNA sequencing methods to identify and characterize the functional elements in the human genome, particularly elements involved in regulating transcription. Our group is one of the leading groups in the ENCODE Consortium, and we are producing large amounts of data for transcription factor binding throughout the genome, RNA expression (mRNAs as well as non-coding RNAs), DNA methylation, and functional validation of identified regulatory elements. The work is intense but very rewarding, producing valuable data for the entire scientific community while also providing opportunities for applying the resources towards understanding human health and disease. The Senior Scientist plays a pivotal, leading role in our group, and will have multiple opportunities for publication, presentations at scientific conferences, mentoring and career development.

This individual will:
● Serve as coordinator of the multiple experimental methods, including ChIP-seq, RNA-seq, DNA methyl-seq, and other high-throughput approaches that we are applying towards annotating the functional elements in the human genome
● Troubleshoot and improve these methods while maintaining the production of large-scale functional genomics data for the project
● Be able to handle and analyze large datasets, working closely with our analytical/computational team
● Supervise several technicians, providing them with day-to-day guidance and training, and analyzing their data for content and quality
● Work closely with graduate students and postdoctoral fellows who also contribute to the ENCODE Project as well as our disease and drug-response genomics/genetics work
● Serve on several ENCODE Consortium working groups, which are involved with strategic planning of the entire ENCODE Project
● Prepare progress reports for our funding agency
● Co-author publications of research findings in scientific journals
● Exhibits deep curiosity and enthusiasm for discovery, encouraging and sustaining the laboratory team even in the case of unexpected setbacks; embraces the ever-changing scientific environment
● Other duties as assigned

The Myers laboratory and HudsonAlpha Institute provide a supportive and friendly environment in a dynamic setting, with additional faculty, postdoctoral fellows and graduate students, computer scientists, statisticians and research technicians. Salary is highly competitive and full benefits are provided.


● Doctoral degree from an accredited institution in life sciences, biostatistics, or related field
● At least 2 years of postdoctoral research experience in a molecular, genetic or genomics laboratory
● Extensive laboratory and research experience that introduces or enhances research capabilities at HudsonAlpha
● Experience in working with large genomic datasets, including basic quality control and data analysis and interpretation. Note experience in computational programming, while helpful, is not required
● A track record of high quality research work as evidenced by published manuscripts
● Experience mentoring and teaching research staff, particularly technicians
● Ability to exercise judgment and distinguish issues that require involvement of faculty investigator
● Experience advising on research methodology and analysis, as well as ability to interpret laboratory results and provide conclusions
● Demonstrated ability to advance projects, managing multiple tasks and priorities
● Proficiency with laboratory software, tools and equipment

Contact Information: 

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About Our Organization: 

HudsonAlpha Institute for Biotechnology is a non-profit institute dedicated to innovative genomic technology and sciences across a spectrum of biological problems. Its mission is three-fold: sparking scientific discoveries that can impact human health and well being; fostering biotech entrepreneurship; and encouraging the creation of a genomics-literate workforce and society. The HudsonAlpha biotechnology campus consists of 153 acres nestled within Cummings Research Park, the nation's second largest research park. Designed to be a catalyst for biotechnology economic development, its state-of-the-art facilities co-locate scientific researchers with entrepreneurs and educators. The relationships formed on the HudsonAlpha campus allow serendipity to yield results in health care.

Since opening in 2008, HudsonAlpha has built a global name for itself in genetics and genomics research, and biotech education, and it boasts 23 biotech companies on campus.