Post-Doctoral Research Fellow, Bioengineering

Organization: 
Fred Hutchinson Cancer Research Center
Job Location: 
Seattle, WA
Job Description: 

About Us
Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, the Center's four scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Hutchinson Center, in collaboration with its clinical and research partners, the University of Washington and Children's Hospital and Regional Medical Center, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Join us and make a difference.

About the Department
A postdoctoral position is available at the Fred Hutchinson Cancer Research Center in Seattle, WA, USA, for a candidate to explore the fast-developing and highly interdisciplinary field of immunobioengineering for adoptive T-cell therapy. Using next-generation immunomodulatory synthetic materials, the postdoctoral fellow will develop new approaches - beyond existing T-cell-based therapies - to therapeutically manipulate the immune system against cancer. Dr. Matthias Stephan's laboratory in the Clinical Research Division is working at the interface of bioengineering and immunology to enhance adoptive T-cell therapy against cancer using synthetic biomaterials (Stephan et al., Nat Med. 2010, Nano Today 2011, Biomaterials 2012).

The postdoctoral fellow will fabricate stimulatory biomaterial devices, drug delivery systems and bioactive substances and test their therapeutic potential in preclinical tumor models of adoptive T-cell therapy. The FHCRC provides one of the nation's top programs for postdoctoral training, in an academic environment with clinical and translational research opportunities.

A highly motivated candidate is sought with a recent PhD in a relevant field, preferably including training in immunology. The candidate must have a strong knowledge of primary immune cell isolation and culture, and advanced training in relevant procedures and the establishment of advanced in vivo murine tumor models. This project will involve frequent and repetitive murine surgery, use of flow cytometry and serial bioluminescent imaging as part of the research, which the ideal candidate will have had experience in as part of their PhD training. The position further requires a basic understanding of genetic engineering and protein expression. The successful candidate will be a scientifically driven, well organized self-starter.

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