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The HIV Vaccine Trials Network (HVTN) Laboratory Center in the Immunology & Vaccine Development Program of the Vaccine & Infectious Disease Division is dedicated to understanding human immune responses and mechanisms of vaccine-induced immune protection against HIV and related related infectious diseases.
This position will be with the HVTN Laboratory Center in the Immunology & Vaccine Development Program within the Vaccine & Infectious Disease Division at FHCRC. The position will involve a supervisory role overseeing detailed evaluation of the immune responses to candidate HIV vaccines in clinical trials as well as investigations of immune responses to HIV and related infections. The position will involve a supervisory role for a good clinical laboratory practices (GCLP) laboratory performing primarily cellular immune function assays.
This individual will assist in the development of assays and design of experiments to examine vaccine immunity and will assist with collection and analysis of data. S/he will assist with implementation of laboratory QC procedures and records. In addition, the candidate will assist with validation of assays and/or equipment for the GCLP laboratory as well as train technical staff. S/he will work in conjunction with the HVTN Laboratory Center GCLP and R&D teams to perform this job. The staff scientist will develop techniques and design experiments to examine vaccine induced immunity, with a special emphasis on early innate immune responses, and will assist with collection and analysis of data.
1. Reporting to the Associate Director, coordinate and carry out the projects of the HVTN Laboratory Center activities with a focus on Endpoint Analysis including but not limited to:
a. Development and execution of GCLP cellular immune function assays including but not limited to multiparameter flow cytometry, (Intracelluar Cytokine Staining), IFN-? ELISpot, Luminex, B-cell ELISpot, viral inhibition, and other assays as relevant.
b. Assistance with establishment of new technologies in the lab
c. Preparation of progress reports, scientific articles and grant applications.
d. Hiring and supervision of laboratory technicians
e. Presentations of data at meetings and conferences
2. Interface with collaborating researchers:
a. Participate in both formal and informal sharing of data amongst collaborating researchers
b. Coordinate establishment of new techniques in the laboratory
c. Interact with key analysis collaborators in other divisions (e.g. SCHARP)
3. Assist with new clinical vaccine trials:
a. Assist with design of new trials to test candidate vaccines and adjuvants
b. Participate in HVTN processes to develop new clinical trials
c. Coordinate and implement specimen collection and analysis within the HVTN
4. Other duties and projects as assigned.
- Candidate must have a M.D. or a Ph.D in Immunology or a related field, with at least 3 years postdoctoral research experience in vaccines. Experience with multiparameter flow cytometry analysis, multiplex bead arrays, and microarray analysis is also required, as well as a willingness to work with biohazardous (e.g., HIV-1, vaccinia) materials. Expertise in human clinical trial development and implementation and GCLP/GCP experience is highly desired.
- Duties will require working in a team-oriented research environment and in serving in a supervisory capacity. A strong background in collaborative team leadership and project completion is preferred, with the ability to create and manage project schedules, including tasks, deliverables, milestones and schedules.
- Excellent communication (oral and written) and problem-solving skills are required. Motivation and adaptability are essential, as is a keen interest in the vaccine field.
- Proficiency in the following computer programs is necessary: MS Office, Illustrator or other drawing program, Prism or other graphing program, JMP and/or SAS statistical analysis program, and FlowJo or other flow data analysis program.
- Hours: Must be flexible, able to work some nights and weekends.
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