UPFellows COFUND Programme

Universitat Pompeu Fabra
Job Location: 
Barcelona, Spain
Job Description: 

Universitat Pompeu Fabra
UPfellows Cofund Programme

Universitat Pompeu Fabra, in Barcelona, Spain, seeks outstanding scientists who have demonstrated (or have strong potential for) innovation and leadership in research, within the framework of the UPFellows programme to integrate them in their departments which cover a broad range of topics. In the Department of Experimental and Health Sciences we specially encourage collaborative interaction and synergies with existing research programmes, while providing novel expertise not currently covered, to maximise the impact of the fellowship in the career development of the candidate. Special areas of interest within this call are:

Control of cell cycle progression by p38 SAPK in mammals
Stress puts cells at risk, and rapid adaptation is crucial for maximizing cell survival. Eukaryotic cells have evolved sophisticated sensing mechanisms and signal transduction systems that can produce accurate dynamic outcomes in response to stress. Activation of SAPKs results in the generation of a set of adaptive responses that lead to the modulation of cell cycle and transcriptional processes.
Candidates with a strong background in mammalian cell biology, gene targeting, cell cycle, transcriptional studies and microscopy, with a good understanding of molecular biology, have a good opportunity to further develop their professional careers in this field.
References: Nature 493(7430):116-9 (2013); EMBO J. 31(13):2952-64 (2012); Nature 469:207-11 (2011); Nat Rev Genet. 12(12):833-45 (2011); Science Signal. 4(192):ra63 (2011).
Contact: Dr. Montse Morillas, montserrat.morillas@upf.edu

Computational System Biology Modelling in Drug Toxicity Prediction
This research will be carried out within the Research Programme on Biomedical Informatics (grib.upf.edu) and, more concretely, in the framework of the eTOX project (www.etoxproject.eu). The proposed topic deals with the application of systems biology approaches for the modelling of drug toxicity, with the aim of providing a mechanistic understanding of the toxic effect of compounds at different levels (pathway, cell, tissue, organ). Candidates with previous experience in the field and interested in developing a professional career in systems biology modelling (qualitative and/or quantitative approaches) applied to biomedical research have an excellent opportunity to acquire innovative skills in an international environment.
Contact: María Jesús Donlo, mdonlo@imim.es

Evolutionary Genomics of humans: the recent signature of selection.
The Evolutionary Biology and Complex Systems Program is carrying out research within the Evolutionary Genomics group (http://biologiaevolutiva.org/anavarro/). Candidates with a background in evolution, population genetics, molecular evolution and bioinformatics (i.e. experience in handling and analyzing NGS data, and familiarity with the basic procedures to detect the signature of positive selection) willing to work on the genomic signature of the action of selection acting upon multiple targets, with especial, but not exclusive, focus on recent epistatic interactions in human populations (population genetic modeling and mining of current databases of human genomes) have an excellent opportunity to advance in their professional career.
Contact: Judit Sainz, judit.sainz@upf.edu

Systems Biology in gene expression
A systems biology (molecular, biochemical, computational and genomic) approach will be used to quantitatively measure how promoters evolve, and to study the effects of different transcriptional regulation mechanisms. Computational modelling and high‐throughput experiments will be combined in order to learn precisely how DNA sequence determines gene expression. The combination of single-cell measurements of gene expression with high-throughput sequencing of libraries of synthetic and native DNA sequences will ascertain the precise molecular mechanisms by which DNA sequence determines gene expression and how regulation evolves from non‐regulatory DNA.
The programme offers candidates with experience in cellular signalling, gene transcription and expression, bioinformatics and systems biology, a good opportunity to advance in their scientific and professional career development.
Contact: Dr Regina López, regina.lopez@upf.edu

Candidates to join the Department of Experimental and Health Sciences are expected to hold a PhD by 30th September, and undertake transnational mobility (not have spent in Spain more than 1 year in the last 3 years immediately prior to the submission of the application).

The UPFellows programme is funded jointly by the Marie Curie COFUND program (7th Framework Program) and the UPF. The fellowships are awarded for a period of 3 years, with a competitive salary and an initial contribution to research costs.

Detailed information on the call and access to online application system can be found at http://www.upf.edu/upfellows/

Applications will include:
- A full CV
- A statement of research interests and plans for the UPFellow period
- The names of three scholars who are willing to serve as references for the applicant
- An indication of which panel the applicant wishes to consider his/her application.

The call will open on June 1st and the application deadline is the 1st of July 2013.

Contact Information: 

For additional information contact upfellows@upf.edu