Computational Biologist

Broad Institute
Job Location: 
Cambridge, MA
Job Description: 

Our group recently developed a technology (Hi-C) for reconstructing the three dimensional architecture of the human genome inside the cell nucleus. This technology relies on proximity ligation followed by high-throughput sequencing. We are now working to extend this technology to probe proximity ligations between DNA, RNA, and other cellular components.

We are looking for a highly motivated computational scientist whose role will include the interpretation of data coming from these and similar high-throughput experiments in terms of the spatial arrangement of cellular components and their role in genetic regulation. You will also need to be able to comprehend complex biological experiments and use that understanding to help refine experimental protocols. The successful candidate will be expected to work regularly with a wide range of large-scale datasets and complex codebases in the effort to do outstanding research. The position involves mixture of algorithm design and implementation, rapid prototyping on data sets, analysis of data sets, creation of web-based interfaces and computational infrastructure, interaction with a wide range of laboratory personnel, and writing for internal use and publication.

You will work in an intense, exciting environment, tackling a wide range of critical issues at the frontiers of contemporary science.

- Work with team to rapidly design and prototype algorithms on large-scale data; implement and optimize successful algorithms.
- Contribute to and maintain shared, documented, and reusable codebases.
- Prepare written reports and proposals for internal use and publication.
- Ability to solve complex problems.
- Excellent communication skills.
- Must possess a high level of initiative and the ability to work with little supervision.
- Strong organizational, time management, and project management skills required.
- Must be able to work independently as well as part of a team in a fast-paced, highly collaborative environment.
- Must be able to interact professionally and collaborate with computational, experimental, and theoretical scientists with expertise spanning a range of disciplines.
- Creativity, curiosity, and the desire, persistence and ability to create scientific advances required.
- Exceptionally deep computational understanding and abilities. Must have strong mathematical and abstract thinking skills, and hands-on ability to turn ideas into highly readable, elegant code. Strong statistical background preferred.
- PhD in math, physics, computer science, or comparable research experience required.
- Strong C++ programming skills and experience in Unix/Linux environment required.
- Knowledge of Javascript, Python, and MySQL a plus.
- Experience in industry is a plus.
- Excellent oral and written communication skills needed.
- Must be capable of self-directed research within broader goals set by group.
- Must be capable of comprehending a complex, existing codebases.

Please be advised this position will be relocated to Houston, Texas in summer 2013 and be employed by another organization.

To apply for this position, please CLICK HERE