Research Scientist – Immunology/Systems Biology/Bioinformatics

Kyowa Hakko Kirin California, Inc.
Job Location: 
San Diego, CA

Medical, Dental and Vision Insurance Life Insurance and AD&D Disability Coverage: Short-Term & Long-Term Plans 401(k) Retirement Plan Sick Leave & Vacation Paid Holidays Discretionary Year End Bonus Monthly Employee Event and Other Company Sponsored Events Onsite Yoga and Masseuse Services

Job Description: 

We are seeking a motivated individual for a unique position that combines bench and computational research in the area of immunology. Key responsibilities include design of experiments, preparation of samples for microarray and gene variant studies, analysis of mid- to large-scale datasets from genomic and proteomic studies for one or more projects, introduction of new technologies, development of new approaches to evaluate test data, and propose new projects to advance target and drug discovery activities of a pharmaceutical company.

Essential Duties and Responsibilities include the following. Other duties may be assigned.
• Work on a small global team to generate and analyze in-house transcriptome, proteome, and genome variant data using best-practice methods and develop novel methods to identify patterns of gene/protein expression, drug targets, biomarkers, and correlations with multiple autoimmune disease parameters from in-house and public data.
• Design and perform necessary wet-lab experiments for gene expression studies and validation of identified targets, and introduce technologies for single cell analysis.
• Implement creative, novel, and practical use of systems biology methods in gene/target discovery, interpretation of cellular processes, and/or biomarker discovery.
• Stay current with scientific literature and bioinformatics community to identify new technologies that enable systems biology approaches to drug discovery for immunological disorders.
• Interact and functionally collaborate with research partners in Biochemistry and Translational Medicine Groups, as well as scientists across KHK Informatics and Immunology groups.
• Discuss findings with team members to evaluate validity of findings and advance the project.
• Present research at group, project, and review meetings, accurately record experiments and data in laboratory notebooks and databases, and record progress in monthly and annual reports.
• Interact within Research Division and upper management to resolve matters pertaining to objectives, plans, or policies.
• Develop, review, and contribute to new project proposals.

To perform the job successfully, an individual should demonstrate the following competencies:
• Demonstrates full use and application of extensive knowledge of scientific principles, theories and concepts in the area of bioinformatics, and statistics.
• Synthesizes complex and diverse information.
• Routinely identifies obstacles to progress and proposes solutions for project advancement.
• Ability to manage multiple tasks and design experimental strategies through to completion in a timely manner and with consistent and reliable results.
• Develop project details with consideration of schedule, cost, reliability, simplicity, and effectiveness.
• Manage more than one project of moderate complexity at a time.
• Quickly adapts to changes in the work environment.

Education and/or Experience:
• Ph.D. from an accredited university with a concentration in biology, bioinformatics, or related field and
• Two to five years of industry or academic experience related to microarray or genome wide expression studies.

Language Skills:
• Ability to read, analyze, and interpret technical procedures and equipment manuals
• Ability to write reports and scientific protocols
• Ability to effectively present information and respond to questions from project team members and executive management
• Ability to constructively discuss scientific topics with other scientists and clinicians at various types of meeting and conferences

Math Ability:
• Proficient in statistical analysis especially feature extraction from diverse datasets.
• Ability to apply mathematical operations to such tasks as frequency distribution, determination of test reliability and validity, analysis of variance, and correlation techniques.

Reasoning Ability:
• Ability to solve practical problems and deal with a variety of concrete variables in situations where only limited standardization exists. Ability to interpret a variety of instructions furnished in written, oral, diagram, or schedule form.

Computer Skills:
• Proficiency with bioinformatics software especially microarray and pathway analysis software such as GeneSpring GX, Integrated Pathway Analysis (IPA), Spotfire.
• Proficiency working with the Microsoft Office suite of programs (Excel, PowerPoint, Word, etc.) and with laboratory software including Prism.
• Ability to learn specialized data analysis software applications.

Supervisory Responsibilities:
May supervise at least one research associate


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The requirements listed below are representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
• In-depth knowledge and well-experienced in bioinformatics and statistics, from planning to execution of whole genome microarray expression profiling and using network, pathway, or signature analysis to interpret the biology of the differentially expressed proteins in their cellular context.
• Experienced at RNA preparation from primary cells for gene expression analysis.
• Design and execute experiments for (in vitro or in vivo) functional evaluation of genes identified in genome-wide studies.
• Broad knowledge base in autoimmune/inflammatory diseases, and sound understanding of molecular biology techniques preferred.
• Ability to function well on diverse teams.
Desired Qualifications:
• Evaluation of data to identify novel pathway and gene function from one or more of the following analyses: next generation sequencing, GWAS, genome-wide epigenetic analysis, or whole genome RNAi screening.
• Familiarity with R and Perl

Contact Information: 

For immediate consideration, qualified candidates are invited to submit their resume or CV & cover letter, referencing the position of interest and desired salary range via email to: or mail to:

Kyowa Hakko Kirin California, Inc.
Attn: Human Resources
9420 Athena Circle
La Jolla, CA 92037

No phone calls please. We thank you for your interest in Kyowa Hakko Kirin California, Inc.!
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About Our Organization: 

At Kyowa Hakko Kirin California, Inc. (KKC), we believe our team is the reason for our success and we are interested in quality people with a winning attitude to join our team!

Kyowa Hakko Kirin California, Inc. is a wholly owned U.S. subsidiary of Kyowa Hakko Kirin. Kyowa Hakko Kirin California was established in San Diego, California in 1988, and acts as KHK's primary drug discovery research facility in the US, facilitating the company's pharmaceutical development efforts in North America. Kyowa Hakko Kirin California utilizes proprietary antibody engineering technologies (including human/humanized antibody and Potelligent) in its research and development program of antibody based therapeutics for infectious and autoimmune diseases.

Our dedicated team is a focused and interactive group involved in pursuing innovative biomedical research and technologies targeted towards the development of novel therapeutics. To further expand our research efforts on infectious diseases and disorders of the immune system, KKC has been a major corporate sponsor of the La Jolla Institute for Allergy and Immunology (LIAI), a not-for-profit research institute, since 1988.

Our dynamic, state-of-the-art facility is located in the UCSD Science Research Park in La Jolla, CA. We take pride in our competitive benefit and compensation programs offered to our full-time employees, placing a high value on wellness.

We are an Equal Opportunity Employer (EOE). All qualified applicants will receive consideration for employment without regard to race, creed, color, sex, gender, religion, marital status, domestic partner status, pregnancy, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, veteran or any other consideration made unlawful by federal, state or local laws, or perceived affiliation with persons belonging to these protected classes.