Regulatory Genomics Project Leader

The Genome Analysis Centre (TGAC)
Job Location: 
Norwich, UK
£33,750 - £45,000
Job Description: 

To lead the Regulatory Genomics Team with responsibility for applying next generation sequencing to the genome wide analysis of gene regulation including analysis of gene expression, DNA methylation and chromatin conformation.

To develop and enhance computational approaches, tools and algorithms that help improve our understanding of gene regulation.

To perform data analysis independently and in collaboration with research groups within and outside the UK.

To establish the direction and priorities of the regulatory genomics team and work alongside the genomics division in establishing novel applications.

To develop the strategic development and delivery of the research priorities at the Centre alongside the Genome Analysis team leader (including exploring funding opportunities and collaborations).


Experience in bioinformatics related to high throughput DNA sequencing.

Experience of working in a rapidly changing technological environment.

Experience in the analysis of sequencing data from RNA-Seq, ChIP-seq, BS-Seq or small RNA experiments

Experience with statistical packages such as R and MATLAB

Excellent communication and leadership skills.

Strong organizational and record keeping skills in data analysis

To be able to communicate clearly with TGAC staff at all levels.

Ph.D. in Bioinformatics or computational biology, or alternatively a Ph.D. in molecular biology with a strong computational emphasis

About Our Organization: 

The Genome Analysis Centre (TGAC) is a vibrant, contemporary research institute and registered charity, working in an area of rapid technological development and innovation.

TGAC is strategically funded by the BBSRC to lead the development of a skill base in bioinformatics and a genomics technology platform for UK bioscience. The Institute is located on the Norwich Research Park, together with its partners: the John Innes Centre, the Institute of Food Research, The Sainsbury Laboratory, the University of East Anglia and the Norfolk and Norwich University Hospital. The research park has an excellent reputation for research in plant and microbial sciences, interdisciplinary environmental science and food, diet and health, to which TGAC contributes strengths in genomics and bioinformatics. Close links exist between the NRP partners and new opportunities for collaboration in exciting new initiatives are under development. The NRP recently received £26M of government investment to facilitate innovation and further develop infrastructure to attract science and technology companies to the Park to enhance the vibrant environment and realise economic impact from research investment.

TGAC is a UK hub for innovative Bioinformatics through research, analysis and interpretation of multiple, complex data sets. It hosts one of the largest computing hardware facilities dedicated to life science research in Europe. This has been boosted recently by an e-Infrastructure grant to expand the data storage capacity to a multi-petabyte unit, deploying a high performance cluster and large-memory server enabling the allocation of processes requiring several terabytes of computing memory.

TGAC’s state of the art DNA sequencing facility operates multiple complementary technologies for data generation that provide the foundation for analyses furthering our fundamental understanding of genomes and how they function. We aim to be at the forefront of technological advances and are developing and implementing technologies to generate and analyse new types of data. We also develop novel platforms to provide access to computational tools and processing capacity for multiple academic and industrial users and promoting applications of computational bioscience. TGAC has one fully owned subsidiary, Genome Enterprise Ltd (GEL) via which it offers genomic and bioinformatics services on a trading basis and works with commercial providers on a partnership basis. TGAC also receives specific funding to enable knowledge exchange programmes which are supported across the institute teams.