Layer, Chiang, et al. Genome Biology
We are looking for enthusiastic students and postdocs to join the Medical Epigenomics Lab at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna. Our group combines experimental and computational methods for understanding epigenome regulation in cancer, stem cells, and immune diseases.
The Medical Epigenomics Lab [http://www.medical-epigenomics.org/]
The lab combines large-scale analysis of the epigenome with stem cell biology and computational modeling, in order to better understand and treat leukemia and other diseases of the blood system. We work closely with biologists and medical researchers at the Medical University of Vienna, aiming to advance personalized medicine through epigenome sequencing and bioinformatic innovation. Specific research interests include (but are not limited to):
• Epigenomics. The lab is part of the BLUEPRINT project aimed at establishing, analyzing and interpreting comprehensive epigenome maps of >100 cell types of the blood and immune system.
• Bioinformatics. We develop bioinformatic methods and infrastructure for analyzing DNA methylation data in the context of epigenome-wide association studies.
• Diagnostics. Using large-scale DNA methylation mapping, bioinformatic prioritization and functional characterization, we strive to develop clinically relevant biomarkers for informing cancer therapy.
The Principal Investigator [http://christoph-bock.org/]
Christoph Bock received his training in computer science and business science from the Universities of Mannheim and Heidelberg (Germany). He obtained a PhD in bioinformatics from the Max Planck Institute for Informatics, for which he was awarded an Otto Hahn Medal by the Max Planck Society. Christoph did his postdoc in epigenome research at the Broad Institute of MIT and Harvard, contributing to the Roadmap Epigenomics Project. In parallel, Christoph led a research group on computational epigenetics at the Max Planck Institute for Informatics. His recent publications include papers in Cell, Molecular Cell, Nature Biotechnology, Nature Methods, Nature Reviews Cancer, Genome Research, Genome Biology, PLoS Computational Biology and Bioinformatics (http://scholar.google.com/citations?user=9qSsTcIAAAAJ). Christoph also co-directs the high-throughput sequencing platform at CeMM, and he is a visiting professor at the Medical University of Vienna as well as a work package leader in the European epigenome mapping project (http://blueprint-epigenome.eu/).
The lab is driven by the ideas of all its members. If you already have a project in mind, we would like to hear from you. If not, here are a few topics for inspiration: (i) Why is leukemia a disease of the elderly? Can we identify an “epigenetic clock” that counts down toward leukemia? What is wrong with this clock in those rare cases of childhood leukemia? (ii) Can we construct a blood cancer from scratch, by inducing only epigenetic defects? Which combination of pathways provides the minimum core of an epigenetic leukemia? (iii) How can we make epigenome data useful for personalized medicine? Every physician uses Google – can we build a “Google for the epigenome”?
We are looking for highly motivated and academically outstanding candidates who want to pursue a scientific career in the emerging field of medical epigenomics. An ideal candidate would have a background in molecular biology (or human genetics, genomics, molecular medicine, etc.) or a computational discipline (bioinformatics, physics, engineering, etc.) and a strong interest in working together with collaborators in the entire spectrum of epigenetics, medical genomics and bioinformatics.
Please submit cover letter, curriculum vitae, academic transcripts and contact details of three referees to firstname.lastname@example.org. Please indicate the correct reference code in the subject line PD Medical Epigenomics.
Deadline for applications: 31 August 2012.
The Institute [http://www.cemm.at/]
The CeMM Research Center for Molecular Medicine is an international and interdisciplinary research institute of the Austrian Academy of Sciences. Driven by medical needs, CeMM integrates basic research and clinical expertise to pursue innovative diagnostic and therapeutic approaches focused on cancer, inflammation and immune disorders. CeMM is located in a new tailor-made building at the center of the Vienna Medical University campus, within walking distance of Vienna’s historical city center. According to a study by “The Scientist”, CeMM is ranked as the best European place to work in Academia 2012, internationally CeMM appears at the fourth place, see: http://the-scientist.com/2012/08/01/best-places-to-work-academia-2012. Vienna is frequently ranked the world’s best city to live. It is a United Nations city with a large English-speaking community. The official language at CeMM is English, as more than 30 different nationalities are represented.