An Assistant Professor in Department of Medical Oncology, Dr. Roychowdhury’s lab focuses application of next generation sequencing for clinical oncology. The lab will evaluate fresh biopsy samples from patients with metastatic disease who are considering clinical trials for novel targeted therapies. Patients are consented to under go sequencing of their metastatic tumors (whole exome, RNASeq) and their germline (whole exome). These data will be analyzed and interpreted through a new Sequencing Tumor Board, and eligible patients will pursue targeted therapies through collaborating clinical trials. Patients participating in subsequent clinical trials will be eligible for repeat tumor biopsy to facilitate understanding of secondary resistance mechanisms to targeted therapies. Topics for the lab will include resistance mechanisms to novel targeted therapies (serial samples from clinical trials), cancer heterogeneity, cancer genomics discovery, and bioinformatics (exome, RNAseq, eventually methylseq and single cell sequencing).
Due to the inter-disciplinary professional work environment of clinical tumor sequencing, we seek an applicant with good communication skills and experience working as part of a team. The selected candidate will be responsible for analysis of next generation sequencing data including exome sequencing, RNA-seq, whole genome sequencing, and other capture-based sequencing data from both cancer and normal tissues. Candidates are expected carry out NGS data analysis, implementing existing tools and pipelines, providing quality control measures, and eventually developing or improving these pipelines/tools in collaboration with our team. As we are dealing with cutting edge technologies and clinical information, the applicant must utilize robust software that can accommodate frequent feature requests and modifications in a timely fashion.