Is There a Problem?

Retractions are becoming a serious issue, researchers say.

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One thing to remember is that

One thing to remember is that in biological experiments
the ratio of the amount of collected data compared to the number of variables is quite low as say compared to a physics or chemistry experiment. This can lead to many and over interpretations of data. Selection of specific experimental results from numerous repeat or similar experiments is also an issue.
Since the measures of scientific success are more publications to get more grant funding and the current competition is quite severe; researchers are going to be more incline to try and publish papers and data that they might not under a system that was more forgiving of the publish or perish para dime.

I think it's also the

I think it's also the accelerating pace of research enabled by technological advancements, both at the bench and at the computer. Datasets are getting bigger and being processed faster, which makes it easy to overlook small problems or inconsistencies. The retraction rate might be another part of the argument for "slow science:" http://slow-science.org/

retraction - you mean

retraction - you mean "paradigm"

Of concern - evidence-based

Of concern - evidence-based medicine relies on skewed statistical methodology for patients care!! Far too reliant on probability and what is found "significant" in statistical tests.

Unacceptable high percentage of peer-reviewed published medical research designed from the onset to show evidence of benefit of medications, diagnostics tests, surgery. Poorly designed, little mention of extraneous variables, contradictory research, fraudulent and biased, confusing to clinicians and patient. Historical schism creating an ever divergence between corporate science and healing/health!!