Illumina Says 'Significant Growth' in Sequencing Demand Drove 12-Percent Rise in Q4 Revenue

The company said it is in discussions with several large genome centers about replacing their Genome Analyzers with the newly launched HiSeq 2000, but stressed it is premature to forecast how many customers will opt to trade up.

Papers of Note

Sequencing-Related Papers of Note, Jan. 2010

Atlas Biolabs to Offer Roche NimbleGen Target-Enrichment, Sequencing Services

Berlin-based Atlas Biolabs recently became certified under Roche NimbleGen's service provider program. It will offer DNA capture services using NimbleGen arrays followed by sequencing on 454's GS FLX.

Helicos to Install Second Sequencer at Stanford; Sells Instrument to Private Research Institute

The Stanford system will be installed in March and is intended to "meet the growing demand for access" to the company's single-molecule sequencing technology. The installation at the St. Laurent Institute is expected to be completed early this month.

Life Tech's $495,000 SOLiD 4 Generates 100 Gb Per Run in Q1; 300 Gb Later This Year

Life Tech is also launching a sample prep instrument to speed up the emulsion PCR, and a three-year, $100 million initiative to address challenges in analyzing and interpreting large amounts of whole-genome sequencing data.

Ignite Institute to Install 100 ABI SOLiD 4 Systems by Year End Under Life Tech Collaboration

According to a company spokesperson, the firm has no other obligations to the institute under the collaboration besides supplying the sequencing instruments and related services.

UCLA Team Sequences Brain Cancer Cell Line with ABI's SOLiD

The scientists said the project illustrates that thorough sequence analyses of cancer genomes can be done quickly, efficiently, and at a low cost outside of the large sequencing centers.

Illumina to Complete Analysis of Ovarian Cancer Set by End of Q1; Move to Validation Phase

Early results indicate that the genomes analyzed so far are "highly rearranged," even though they were derived from early-stage tumors, and that there is "a lot of heterogeneity" between them.

Life Tech Says Phase-Out of CE Systems is 'Largely Complete' as Next-Gen Sequencing Gains Traction

Life Technologies officials said that less than 5 percent of the company's revenue currently comes from next-generation sequencing, but forecast double-digit growth of next-gen revenues in 2010.

Oxford Nanopore Raises $28M from Multiple Investors; Embarks on Protein Analysis Application

Oxford Nanopore, which has been developing a real-time label-free single-molecule DNA sequencing technology as its lead application, plans to use part of the new investment to develop its platform for protein analysis.

Roche's 454 Eyes Immune Repertoire Sequencing as Key Application for Long-Read Platform

Some researchers are looking at short-read platforms such as the Illumina Genome Analyzer for immunogenetics applications, but a 454 official said that the long read lengths of the company's platform — currently in the range of 400 or more base pairs — make it ideal for immunogenetics research.

Beckman Coulter Genomics, Genpathway Partner to Provide ChIP-seq Service

The new service, which is available worldwide, expands Beckman Coulter Genomics' DNA sequencing applications portfolio and makes use of Genpathway's experience with chromatin immunoprecipitation.

New Products

MIRA 3.0.0, Bioo Scientific Air Barcoded Adapters, Epicentre Nextera Kits for Illumina Libraries