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Tuesday, February 7, 2012
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Home » News » Pharmacogenomics Reporter
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FDA Official Says Personalized Medicine Regulation Taking Shape Following Zelboraf, Xalkori Success

 

February 01, 2012

Myriad to Double Sales Force for Prolaris Prostate Cancer Dx

 

February 01, 2012

Montreal Heart Institute Developing GnuBio Sequencing Panel for Sudden Cardiac Death Test

 

February 01, 2012

In Draft Research Agenda, PCORI Leaves Room for CER on Personalized Medicine, but Without Specifics

 

February 01, 2012

European Regulatory Body Seeks Stakeholder Input on Future PGx Guidance

 

February 01, 2012

MDx/CDx Focus: FDA Accepts Pfizer's Bosutinib NDA; Kalydeco Approval; AssureRx Credit Line; and more

 

February 01, 2012

People in the News: Manohar Furtado, Carolyn Compton, Raymond Woosley

 

February 01, 2012

Genomic Health to Launch NGS-based Somatic Cancer Mutation Detection Platform for Pharma Research

 

January 25, 2012

Foundation Medicine Highlights Actionable Data from First Patient Samples Analyzed on NGS Cancer Dx

 

January 25, 2012

Exclusive License to RAD51C Gene Could Lead to New Myriad Test for Breast, Ovarian Cancer Risk

 

January 25, 2012

Sequencing Study Suggests Potential New Treatments for ALL Subset with Poor Response

 

January 25, 2012

Avalere Predicts Genomic Medicine Interventions will be Subject of CMS National Coverage Decisions

 

January 25, 2012

Genomic Health Hopes Decision-Making Study Results Will Drive Colon Cancer Dx Adoption, Payment

 

January 25, 2012
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In last week's issue of Pharmacogenomics Reporter

  • Genomic Health to Launch NGS-based Somatic Cancer Mutation Detection Platform for Pharma Research
  • Foundation Medicine Highlights Actionable Data from First Patient Samples Analyzed on NGS Cancer Dx
  • Exclusive License to RAD51C Gene Could Lead to New Myriad Test for Breast, Ovarian Cancer Risk
  • Sequencing Study Suggests Potential New Treatments for ALL Subset with Poor Response
  • Video Spotlight

    ScienceOnline2012

    See video

    Genome Technology's Tracy Vence interviewed Sandra Porter, president of Digital World Biology, and Kristi Holmes, a bioinformaticist at the Becker Medical Library, Washington University School of Medicine at ScieneOnline2012.

    February 02, 2012

    Sponsored Video: Sage Science - Pippin DNA Size Selection

    See video

    Sage Science is pleased to announce the introduction of the BluePippin DNA size selection system, a pulsed-field electrophoresis version of its popular Pippin Prep instrument.

    January 31, 2012

    Highlights from SC11 Part IV

    See video

    In this video, we speak with Todd Smith, senior leader of research and applications of PerkinElmer, and researchers from Stockholm University on accelerating the GROMACS molecular dynamics software suite with GPUs and CPUs.

    January 13, 2012

    Mass Spec at NYU

    See video

    We visited the NYU Protein Analysis Facility at the Skirball Institute of Biomolecular Medicine in New York City and discussed the facility's gear and its development with director, Thomas Neubert.

    January 01, 2012
  • Young Investigator Profile

    Uttiya Basu

    Assistant Professor
    Columbia University

    Alterations & Adaptations

    The Basu research group is looking at how activation induced cytidine deaminase (AID) predominately targets V genes and switch sequences, the mechanisms by which physiological targets of AID are repaired in a mutagenic fashion in B cells, how AID is prevented from acting as a pleiotropic cellular mutagen, and the physiological role of AID in non-B cells.

  • Blog

    A Clearer Way

    The career path for medical laboratory scientists needs to be better defined, Dark Daily says.

    February 06, 2012

    Cleaning up Messy Data with Google Refine

    iPhlyo has a post demonstrating how to use Google Refine, a freely available web-based tool, to clean up messy data.

    February 06, 2012

    This Week in Clinical Chemistry

    In Clinical Chemistry this week: fetal diagnostics, testing exhaled air, and more.

    February 06, 2012

    This Week in PLoS

    In PLoS this week: rare base-pair variation in complex traits and diseases; diagnostic and prognostic markers for infective endocarditis; more.

    February 06, 2012
  • Papers of Note

    Chromosome-Scale Selective Sweeps and Genomic Diversity in C. elegans
    Andersen, Gerke et al., Nature Genetics
    Researchers at Princeton University and elsewhere discuss the effects of chromosome-scale selective sweeps on genomic diversity in Caenorhabditis elegans. Taking a high-throughput selective sequencing approach on a collection of 200 wild C. elegans strains, the team found that the nematode's "genome variation is dominated by a set of commonly shared haplotypes on four of its six chromosomes, each spanning many megabases." Further, the team reports on its population genetic modeling experiments, which showed that "this pattern was generated by chromosome-scale selective sweeps that have reduced variation worldwide; at least one of these sweeps probably occurred in the last few hundred years," it writes.

    Dissecting the Regulatory Architecture of Gene Expression Quantitative Trait Loci
    Gaffney, Veyrieras et al., Genome Biology
    A team led by investigators at the University of Chicago this week report their use of a "Bayesian hierarchical model to estimate the enrichment of eQTLs [expression quantitative trait loci] in a wide variety of regulatory annotations" derived from 1,000 Genomes Project data. "We find that [approximately] 40 percent of eQTLs occur in open chromatin, and that they are particularly enriched in transcription factor binding sites, suggesting that many directly impact protein-DNA interactions," the authors write.

  • People on the Move

    Life Technologies this week named Alan Sachs as head of global research and development and Ronnie Andrews as president of medical sciences.

    Sachs was previously the vice president of exploratory and translational sciences for Merck Research Laboratories, where he spent 10 years in various leadership roles, Life Tech said. Prior to that Sachs served an associate professor of biochemistry and molecular biology at the University of California, Berkeley, and as a Whitehead fellow at the Whitehead Institute for Biomedical Research.

    Andrews joins Life Tech from GE Molecular Diagnostics, where he served as a segment leader following GE's 2010 acquisition of Clarient, where Andrews was CEO. Andrews has also held executive positions with Abbott Diagnostics, Roche Diagnostics, and Immucor.


    Stephen O'Brien has left the National Cancer Institute's Laboratory of Genomic Diversity after 25 years to help launch a genome bioinformatics program at St. Petersburg University in Russia. O'Brien received a $5 million grant from the Russian Ministry of Education and Science last year under a program that aims to lure big-name researchers to Russia. Over the coming three years, O'Brien will spend at least four months per year in Russia working at the center, which is scheduled to open in May.


    Saladax Biomedical said today that President and CEO Edward Erickson has resigned due to personal and family reasons, and that he will be replaced by Kevin Harter on an interim basis. Erickson will remain a member of the company's board of directors. Harter is a co-founder and senior VP of the Life Sciences Greenhouse, and he has served as executive chairman at Saladax.

  • Upcoming Events

    Conferences, Meetings & Deadlines

    The World Cancer Immunotherapy Conference: Challenges & Opportunities in Clinical Development, Clinical Trial Design & Commercialization
    Jan 25-26 / San Diego
    Arrowhead Publishers

    3rd Annual Health Outcomes and Pharmacoeconomics Research Conference
    Jan 30-31 / Philadelphia
    Marcus Evans

    2012 Genitourinary Cancers Symposium
    Feb 2-4 / San Francisco
    ASCO

    An Introduction to Genomics: Breast Cancer Diagnosis and Treatment
    Feb 3 / Bethesda, Md.
    NHGRI

    SLAS 2012: 1st Annual Conference and Exhibition
    Feb 4-8 / San Diego
    SLAS

    Abstract & Registration Deadlines

    more
  • Science

    Members of the International Stroke Genetics Consortium and the Wellcome Trust Case Control Consortium 2 did a GWAS involving thousands of individuals of European descent with or without a history of stroke and found a new genetic variant that contributes to a form of stroke called large vessel ischemic stroke. The variant was found in in the histone deacetylase 9 coding gene HDAC9 on chromosome 7.
  • Business

    PerkinElmer reported fourth-quarter revenue growth of 15 percent, or 6 percent organically, compared to Q4 2010 and beat analysts' estimates on the top and bottom line. The firm is in the process of integrating Caliper Life Sciences and a few bioinformatics companies, and company officials said there would be a pause in M&A activity for the next several months - though diagnostics remains a "significant priority."
  • Funding

    Canada launched a new program that will pump C$67.5 million (US$67.3 million) into projects that will use genomics-based research to advance personalized healthcare. The 2012 Large-Scale Applied Research Project Competition in Genomics and Personalized Health is funded with C$40 million from Genome Canada, C$22.5 million from the Canadian Institute of Health Research, and C$5 million from the Cancer Stem Cell Consortium.
  • Genome Technology Magazine

    The National Center for Biotechnology Information's Teresa Przytycka and her team have developed a pathway-centric computational approach, which is based on eQTL analysis, graph theoretical techniques, and combinatorial algorithms, to identify causative genes for complex diseases. In a paper, her team applied the approach to glioblastoma multiforme, and they identified not only putative causal genes, but also potential nodes and pathways linking those genes.

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