Melanoma Genome Sequence Shows PREX2 as a Significantly Mutated Gene
Berger, Hodis et al., Nature
A team led by investigators at the Broad Institute reports having sequenced the genomes of 25 metastatic melanomas and matched germline DNA, through which it identified a "wide range of point mutation rates," and PREX2 as a significantly mutated gene in melanomas.
Cover Story
Send Out the Work
It does not always make sense for researchers to do their sequencing work themselves. There are an increasing number of researchers who choose to outsource their work, and an increasing number of service providers to choose from.
Feature Story
Cause and Consequence
Fluorescent reporter studies shone a light on the stochastic nature of gene expression more than a decade ago. Now, biophysicists and systems biologists lead the charge to chart how and why single cells and molecules behave the way they do, and the consequences of that behavior.
Climate Change Genomics Heats Up
With climate change starting to have a measurable impact on the world, genomics researchers are teaming up with earth scientists to gain a comprehensive understanding of how climate change and other environmental disturbances may affect the Earth's living organisms.
Project Spotlight
Researchers are using genomics to understand and overcome a deadly citrus disease, and to breed better fruits.
Primer
From the editor
Markers
Study Says Predictive Whole-Genome Sequencing Is Probably Not Very Useful
AACR
UCLA Team Identifies Key Genes Involved in Post-Traumatic Stress Disorder
MDx
UBC Researchers Developing a Sunflower Reference Genome
JGI user meeting
New Simulation Method Sheds Light on the Evolution of HIV
Bioinformatics
Intelligent Bio-Systems Unveils a New Sequencing Machine
ABRF
New Book Takes a Look at What's Underneath Americans' Skin
Book review
News in brief
Brute Force
Government agencies and private companies use powerful analytical methods to handle big data every day. Now, some aim to apply those approaches to genomics.
Where Are They Now?
Pharma Dives into PGx, Roche Acquires 454 Life Sciences, and Microbiome Studies Make Their Debut
In review
Q&A
A new European Union-led consortium aims to foster international collaborations to refine biomarker data for neurodegenerative diseases.
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