Chromosome-Scale Selective Sweeps and Genomic Diversity in C. elegans
Andersen, Gerke et al., Nature Genetics
Researchers at Princeton University and elsewhere discuss the effects of chromosome-scale selective sweeps on genomic diversity in Caenorhabditis elegans. Taking a high-throughput selective sequencing approach on a collection of 200 wild C. elegans strains, the team found that the nematode's "genome variation is dominated by a set of commonly shared haplotypes on four of its six chromosomes, each spanning many megabases." Further, the team reports on its population genetic modeling experiments, which showed that "this pattern was generated by chromosome-scale selective sweeps that have reduced variation worldwide; at least one of these sweeps probably occurred in the last few hundred years," it writes.
Nanogen Seeks Buyer for Microarray Business As It Focuses on Other MDx, PoC Technologies
September 19, 2007
Nanogen cited the drain on its financials and the slow pace at which multiplex molecular diagnostics, such as those being developed on its NanoChip 400 instrument, have been adopted by the healthcare market as primary reasons for its decision.
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