Regulation and Function of miR-218 in Gastric Cancer Metastasis
Tie, Pan et al., PLoS Genetics
Researchers describe a negative feedback system between Robo1, a Slit receptor, and miR-218, wherein “decreased miR-218 levels eliminate Robo1 repression, which activates the Slit-Robo1 pathway through the interaction between Robo1 and Slit2, thus triggering tumor metastasis.” The authors suggest that the restoration of miR-218 supresses Robo1 espression and inhibits tumor cell invasion.
Medical College of Wisconsin Reports 13 Percent Spike in Q1 Operating Revenues
MCW also saw its investment income drop 11 percent in the first three months of its fiscal year, though results suggest that the medical college's investment declines have slowed down from a year ago.
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