Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Wiki-Based Annotation Takes Off in 2008, But Some Say Data-Mining Tools are Lacking
In a recent example of the growing influence of wiki technology in the genomics community, RNA Biology will make authors furnish a Wikipedia entry along with their manuscripts for a new section in the journal. But as this approach gains in popularity, some see the lack of data-mining tools for wiki entries as an obstacle.
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