Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Sun Blade System at Tokyo's Human Genome Center Debuts on Top500 Supercomputer List
A 5,760-core Sun Microsystems blade system at the University of Tokyo's Human Genome Center is the second-fastest life science computer on the latest Top500 list. It follows the 97.1-teraflop, 18,176-core "Chinook" HP cluster at Pacific Northwest National Laboratory’s Environmental Molecular Sciences Laboratory, which holds the No. 34 spot in the current list.
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